Lower the cost of every study you run. Then open the next one.
Grading, attribution and reporting run inside the coordinator hours you already staff, so each study costs less to deliver and the team you have goes further. The technology fee sits in the study contract, the way your CTMS fee already does.
every trial mapped to its version
CTCAE v6.0
new protocols
CTCAE · Diarrhea
v5.0 · Grade 2
v6.0 · Grade 2
protocol cites v6.0
criterion resolved per protocol · cited at grade time
CTCAE v5.0
ongoing trials
one engine, both versions live
Your trial count can grow while your roster stays the same.
Nebraska Hematology Oncology went from no trials in 2024 to nearly fifty active. Burna drafts the grade, the attribution and the report, so each new study lands as a page your coordinator reviews.
Illustrative rendering. Nebraska Hematology Oncology, physician owned, went from no trials in 2024 to nearly fifty active.
One engine carries both CTCAE versions for your team.
A coordinator grading against v6 on a new study and v5 on a study that opened last year is holding two standards in their head, and the differences are substantive.
Burna grades each study against the version its protocol names and shows the governing criterion either way, so the answer comes from the criteria every time.
Ongoing trials
CTCAE v5.0
New trials
CTCAE v6.0
one engine, version-matched criteria
Two live versions, one engine.
Write it into the study contract, the way you already do.
Sites negotiate an electronic systems or technology fee with each industry sponsor, to cover the CTMS and the other platforms they are required to run. Burna fits the same line. Your sponsor gets cleaner data and earlier signals, and you keep the staffing headroom.
You train a coordinator for a year, and then they move on.
Coordinator turnover has run 35 to 61% annually since 2020, and a replacement takes 6 to 12 months to reach full speed. Grading time recovered is time your coordinator spends on the study, and it may be how you fund a raise.
Sources: AACI 2022 CTO Staff Retention Task Force.
Cycle 2 · Diarrhea
Grade trajectory
now G2
Illustrative rendering
Cycle 3 · Neutropenia
Grade trajectory
now G2
Illustrative rendering
Cycle 4 · Fatigue
Grade trajectory
now G2
Illustrative rendering
“If I'm going to go to our CEO, I would have to justify and say: look, I see this allowing us to open up this many more trials, or have this many more patients on study, because my sub-I is now only taking two minutes to review this AE rather than a half hour trying to sort through all of the AEs that occurred since the last visit.”
The query is answered before it's ever asked.
Activation timelines are under pressure, and every open query is time added to database lock. Burna grades arrive with their citations already attached, and gaps surface while the note is still open, months before the next monitor visit.
A new coordinator can practise before they touch a real case.
A new coordinator learns grading from whoever has time to teach it, and the standard drifts with each handover. Burna’s calibration mode lets them grade a synthetic case and compare against the engine’s reasoning, criterion by criterion, before they touch a real one.
Our methodology is public and our results go to peer review.
We publish methodology and pursue peer-reviewed abstracts with partner centers. Burna AI is a participant in Mayo Clinic Platform_Accelerate, where a 1,600-case concordance study is running across three campuses against an adjudicated clinician reference panel. Results read out in December 2026.
Ask us about co-authorship.